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1994-09-19
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Document 0304
DOCN M9490304
TI Delta opioid receptor gene expression in lymphocytes.
DT 9411
AU Chuang LF; Chuang TK; Killam KF Jr; Chuang AJ; Kung HF; Yu L; Chuang RY;
Department of Medical Pharmacology and Toxicology, University of;
California, Davis 95616.
SO Biochem Biophys Res Commun. 1994 Aug 15;202(3):1291-9. Unique Identifier
: AIDSLINE MED/94338340
AB Previous studies have shown that morphine stimulates simian
immunodeficiency virus (SIV) replication in SIV-infected human CEM x174
cells as well as in monkey lymphocytes through a mechanism of delaying
the lysis of infected cells (Biochem. Biophys. Res. Commun.
195:1165-1173, 1993). The present study describes the identification of
brain-like opioid receptor sequences in RNA transcripts of both CEM x174
cells and monkey lymphocytes. Study of the gene sequence of a lymphocyte
opioid receptor encompassing the third transmembrane domain and the
third cytoplasmic loop indicates a 96% homology in amino acid
composition to the delta opioid receptor in brain cells. Expression of
such an opioid receptor sequence in lymphocytic cells is constitutive,
since it could be detected in both saline-treated and morphine-treated
monkeys as well as in morphine-treated monkeys after detoxification.
DE Amino Acid Sequence Animal Base Sequence Blotting, Southern
Brain/METABOLISM Cells, Cultured DNA Primers *Gene Expression Human
Lymphocytes/*METABOLISM Macaca mulatta Male Molecular Sequence Data
Polymerase Chain Reaction Receptors, Opioid, delta/*GENETICS RNA,
Messenger/GENETICS/METABOLISM Sequence Homology, Amino Acid Support,
U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).